SSCE HSC Biology Inheritance patterns in a population: Huntington’s disease is an autos

Question

Huntington’s disease is an autosomal dominant condition caused by a mutation of a gene on chromosome 4. It causes nerve cells to break down.

Stargardt disease is an autosomal recessive condition caused by a mutation of a different gene on chromosome 4. It causes damage to the retina.

A patient is heterozygous for both Huntington's (Hh) and Stargardt disease (Rr). His father's extended family has numerous cases of both of these diseases. His mother does not have either disease and is homozygous for both genes.

(a) Complete the tables, showing the TWO alleles the patient inherited from each parent.

| Alleles from father | Alleles from mother |
|---------------------|---------------------|

(b) The diagram shows the patient’s homologous pair of chromosome 4 at various stages of meiosis.

Add the relevant alleles to the diagram to model the production of possible game combinations. Include a key and an example of crossing over.

Huntington’s disease is an autosomal dominant condition caused by a mutation of a gene on chromosome 4 - HSC - SSCE Biology - Question 28 - 2019 - Paper 1

Worked Solution & Example Answer:Huntington’s disease is an autosomal dominant condition caused by a mutation of a gene on chromosome 4 - HSC - SSCE Biology - Question 28 - 2019 - Paper 1

Complete the tables, showing the TWO alleles the patient inherited from each parent.

Add the relevant alleles to the diagram to model the production of possible game combinations. Include a key and an example of crossing over.

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