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Monoclonal antibodies (mAbs) have been the focus of much attention in the fight against cancer - VCE - SSCE Biology - Question 26 - 2023 - Paper 1
Question 26
Monoclonal antibodies (mAbs) have been the focus of much attention in the fight against cancer. The basic process of monoclonal antibody production is summarised in ... show full transcript
Worked Solution & Example Answer:Monoclonal antibodies (mAbs) have been the focus of much attention in the fight against cancer - VCE - SSCE Biology - Question 26 - 2023 - Paper 1
Step 1
A. The monoclonal antibodies produced by one hybrid cell are identical to each other.
Answer
This statement is correct. Monoclonal antibodies are produced from a single hybridoma, which is a fusion of a specific B cell and a myeloma (cancer) cell. As a result, all antibodies produced from this hybridoma are clones of a single type, meaning they are identical.
Step 2
Step 3
C. The cancerous B cells are extracted from the mouse.
Answer
This statement is partially misleading. While hybridoma cells are created by fusing normal B cells with cancerous myeloma cells, the B cells used in the fusion come from the mouse that has been immunized with the antigen, but they are not directly extracted as cancerous B cells.
Step 4
D. The antigens are combined with cancerous B cells.
Answer
This statement is also incorrect. The process involves combining the antigens with normal B cells obtained from the mouse that have been activated by the antigen, which are then fused with cancerous myeloma cells to produce hybridomas.