SSCE VCE Chemistry Families of Organic Compounds: Paracetamol is a commonly used p

Question

Paracetamol is a commonly used painkiller. The equation below shows one method of preparing paracetamol.

4-amino-phenol + [Possible Reagent] → paracetamol

a. In the box provided in the equation above, give the formula of a possible reagent that can be used in this synthesis.

b. A student uses thin layer chromatography (TLC) to analyse the products of this preparation of paracetamol. For the stationary and mobile phases used for this analysis, the Rf value of paracetamol is 0.4.

i. On the diagram of a TLC plate below, use a horizontal line to mark the spot where paracetamol would appear in such an analysis.

[Diagram]

solvent front →

origin →

0
1
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ii. 4-aminophenol adsorbs less strongly than paracetamol onto the stationary phase of this TLC plate. Predict whether the Rf value of 4-aminophenol in this analysis is greater or smaller than that of paracetamol, giving a reason for your choice.

Paracetamol is a commonly used painkiller - VCE - SSCE Chemistry - Question 3 - 2008 - Paper 1

Worked Solution & Example Answer:Paracetamol is a commonly used painkiller - VCE - SSCE Chemistry - Question 3 - 2008 - Paper 1

a. Give the formula of a possible reagent that can be used in this synthesis.

b. i. On the diagram of a TLC plate below, use a horizontal line to mark the spot where paracetamol would appear in such an analysis.

b. ii. Predict whether the Rf value of 4-aminophenol in this analysis is greater or smaller than that of paracetamol, giving a reason for your choice.

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