Photo AI
The function of a protein is dependent on its three-dimensional structure - VCE - SSCE Chemistry - Question 15 - 2006 - Paper 1
Question 15
The function of a protein is dependent on its three-dimensional structure. This structure can be disrupted, denaturing the protein. Which of the following changes co... show full transcript
Worked Solution & Example Answer:The function of a protein is dependent on its three-dimensional structure - VCE - SSCE Chemistry - Question 15 - 2006 - Paper 1
Step 1
I the addition of a strong acid
Answer
The addition of a strong acid can lead to denaturation of proteins by disrupting ionic and hydrogen bonds, affecting the protein's structure. When a strong acid is introduced, the pH drops, resulting in the protonation of side chains in amino acids, which can disrupt interactions that stabilize the three-dimensional structure.
Step 2
II the addition of a strong base
Answer
Similarly, the addition of a strong base can also cause denaturation. A strong base raises the pH, resulting in the deprotonation of functional groups on amino acids, which can destabilize the protein structure through loss of ionic interactions and hydrogen bonds.
Step 3
III a significant increase in temperature
Answer
A significant increase in temperature can lead to denaturation as well. Elevated temperatures can increase molecular motion, resulting in the disruption of weak interactions such as hydrogen and van der Waals forces, thus leading to the unfolding of the protein.