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Haemophilia is a recessive sex-linked genetic disorder - Edexcel - GCSE Biology - Question 4 - 2016 - Paper 1

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Haemophilia is a recessive sex-linked genetic disorder. The letter h is used for the recessive allele and H for the dominant allele. The diagram shows the inheritanc... show full transcript

Worked Solution & Example Answer:Haemophilia is a recessive sex-linked genetic disorder - Edexcel - GCSE Biology - Question 4 - 2016 - Paper 1

Step 1

Complete the sentence by putting a cross (✓) in the box next to your answer. The genotype of person E is

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Answer

The genotype for person E is X^H X^h. This indicates that person E is a heterozygous female carrier of the haemophilia allele.

Step 2

Calculate the probability of person F and person G having a child with haemophilia. Use the Punnett square for your answer.

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Answer

To calculate the probability, we first identify the genotypes:

  • Person F: X^H Y (affected male)
  • Person G: X^H X^h (heterozygous female)

Constructing the Punnett square:

        |  X^H   |  X^h   |
-------------------------
  X^H |  X^H X^H |  X^H X^h |
-------------------------
   Y  |  X^H Y   |  X^h Y   |

From the Punnett square, we can see the possible genotypes of the offspring:

  • X^H X^H (not haemophilic)
  • X^H X^h (carrier, not haemophilic)
  • X^H Y (not haemophilic)
  • X^h Y (haemophilic)

Thus, the probability of having a child with haemophilia is 1 out of 4, or 25%.

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