Succinate dehydrogenase is an enzyme that catalyses a reaction in the citric acid cycle as shown in the diagram - Scottish Highers Biology - Question 10 - 2023
Question 10
Succinate dehydrogenase is an enzyme that catalyses a reaction in the citric acid cycle as shown in the diagram.
Malonate is a competitive inhibitor of succinate de... show full transcript
Worked Solution & Example Answer:Succinate dehydrogenase is an enzyme that catalyses a reaction in the citric acid cycle as shown in the diagram - Scottish Highers Biology - Question 10 - 2023
Step 1
A. Succinate and malonate have a higher affinity than fumarate for the active site of succinate dehydrogenase.
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Answer
This statement is false. Competitive inhibitors like malonate bind to the active site of the enzyme, which means that fumarate will have a lower affinity under these conditions.
Step 2
B. Increasing the concentration of fumarate would reverse the inhibition of succinate dehydrogenase.
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Answer
This statement is true because increasing fumarate concentration will outcompete the malonate inhibitor, allowing succinate dehydrogenase to function properly.
Step 3
C. Increasing the concentration of succinate would have no effect on the inhibition of succinate dehydrogenase.
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Answer
This statement is false. Increasing succinate concentration may help to displace malonate from the active site, potentially reducing the inhibition.
Step 4
D. Malonate and succinate bind to different sites on succinate dehydrogenase.
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Answer
This statement is false. Malonate is a competitive inhibitor and directly competes with succinate for the same active site.
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