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The Structure of the Nephron Simplified Revision Notes

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6.4.9 The Structure of the Nephron

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The nephron is the functional unit of the kidney, responsible for the filtration of blood and the formation of urine. It consists of several specialised structures, each adapted for a specific role in this process. The human kidney has the following general structure:

Kidney Structure:

  1. Fibrous Capsule:
  • The outer layer of the kidney that protects it from damage and infection.
  1. Cortex:
  • The outer region of the kidney containing:
  • Bowman's capsules: Sites where filtration begins.
  • Convoluted tubules: Proximal and distal tubules for reabsorption and secretion.
  • Blood vessels: Deliver blood to the nephrons.
  1. Medulla:
  • The inner region of the kidney containing:
  • Loops of Henle: Create a concentration gradient for water reabsorption.
  • Collecting ducts: Transport urine towards the renal pelvis.
  • Blood vessels: Network of capillaries aiding in exchange processes.
  1. Renal Pelvis:
  • A funnel-shaped cavity that collects urine from the collecting ducts and delivers it to the ureter.

Nephron Structure:

  1. Bowman's Capsule:
  • Cup-shaped structure surrounding the glomerulus where ultrafiltration occurs.
  1. Proximal Convoluted Tubule (PCT):
  • Reabsorbs glucose, amino acids, salts, and water into the blood.
  1. Loop of Henle:
  • Descending limb: Permeable to water, not salts.
  • Ascending limb: Permeable to salts, not water.
  • Creates a concentration gradient in the medulla.
  1. Distal Convoluted Tubule (DCT):
  • Adjusts the concentration of salts and controls pH through selective reabsorption.
  1. Collecting Duct:
  • Reabsorbs water under the influence of antidiuretic hormone (ADH).
infoNote

Exam Tip:

Understand how the structure of each part of the nephron relates to its function in filtration, reabsorption, and secretion. Be prepared to label a diagram of the nephron and explain processes occurring at each stage.

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